BDBM293563 US10106527, Compound 273::US10544128, Compound 273::US10604514, Compound 76::US11548872, Compound 273::US20230286945, Compound 273::US9951048, Compound 273

SMILES Cn1cncc1-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCOCC3)cc2c1

InChI Key InChIKey=ZABAYWAGMFKGHJ-UHFFFAOYSA-N

Data  12 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 293563   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM293563(US10106527, Compound 273 | US10544128, Compound 27...)
Affinity DataEC50:  2.90E+3nMT: 2°CAssay Description:Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are prepared in 1× Kinase buffer to final concentrations of 0.04 μg/mL, 46 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM293563(US10106527, Compound 273 | US10544128, Compound 27...)
Affinity DataEC50:  2.90E+3nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM293563(US10106527, Compound 273 | US10544128, Compound 27...)
Affinity DataEC50:  2.90E+3nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM293563(US10106527, Compound 273 | US10544128, Compound 27...)
Affinity DataEC50:  2.07E+3nMAssay Description:Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are prepared in 1× Kinase buffer to final concentrations of 0.04 μg/mL, 46 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM293563(US10106527, Compound 273 | US10544128, Compound 27...)
Affinity DataEC50:  2.90E+3nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent